Recommendations are further made to improve efficacy, reduce potential complications, and standardize techniques for future studies. Inconsistencies in methodological design and outcome parameters prevent any robust conclusions. Short-term MSC transplantation is safe and effective however, additional, larger, and higher-quality studies are needed to assess the long-term safety and efficacy. This is the first systematic review to assess the safety and efficacy of MSCs for the treatment of disc degeneration. Overall, evidence suggested that MSCs increased disc space height in the majority of animal models. A 2.7% overall complication rate was noted, whereby complications were noted only in rabbits. With the revolutionary ability to promote. Bone-marrow-derived MSCs demonstrated superior quality of repair compared with other non-MSC treatments. At Nuvo Spine, we are proud to offer you the latest advancements in using Stem Cell Therapy for pain management.
All three types of MSCs (ie, bone marrow, synovial, and adipose tissues) showed successful inhibition of disc degeneration. The studies represented 862 discs that were injected with MSCs and 1,603 discs as controls. Trials in humans fulfilling inclusion criteria were not noted. Twenty-four animal studies were included with 20.8% of the studies reporting randomization of groups.
#STEM CELL TREATMENT FOR DEGENERATIVE DISC DISEASE REVIEWS TRIAL#
Trial design, subject-type, MSC sources, injection method, disc assessment, outcome intervals, and complication events were assessed. Literature databases were extensively searched. Studies that investigated treatment for discogenic pain in lumbar DDD, including any type of stem cell or bone marrow concentrate as the treatment agent and. The aim of this study was to perform a systematic review of comparative controlled studies that have assessed the safety and efficacy of using MSCs for disc regeneration. Mesenchymal stem cells (MSCs) have been used to “regenerate” the disc. Intervertebral disc degeneration is associated with low-back pain.
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